Close

KP-URIC ACID ELIMINATOR
Kidney Pathway
MORUS ALBUS

SOURCE AND CHEMICAL COMPOSITION:
Morus albus (Chinese name Sang Shen Zi) is a concentrated extract of a mulberry fruit. The active ingredient of morus albus is 3,5,7,2',4'-pentahydroxyflavone (morin).

MECHANISM OF ACTION:
3,5,7,2',4'-pentahydroxyflavone is shown to inhibit uric acid reabsorption by kidneys, therefore enhancing kidney clearance of urates. The identified molecular target for morin is human urate anion transporter hURAT1. It has been demonstrated that morin is 25 times more efficient than prescription drug probenecid in enhancing uric acid clearance via kidneys.

HUMAN EXPERINCE:
Morus albus has been used for centuries to relieve symptoms of gout by Traditional Chinese Medicine. However, no formal clinical trials regarding the efficacy of morus albus in patients with impaired uric acid metabolism was published.

PREGNANCY AND LACTATION:
The remedy should be avoided during pregnancy and lactation.

INTERACTIONS:
Based on the Morus albus mechanism of action, the remedy can potentially interact with metabolism of beta-lactam antibiotics, acetaminophen, aspirin and other NSAIDs, rifampin, benzodiazepins and methotrexate. Therefore, morus albus should be avoided in patients taking aforementioned medications.

ADVERSE REACTIONS:
Morus albus extract contains a tyrosinanse inhibitor. Therefore, prolong use of morus albus can cause skin whitening / hypopigmentation. People with known history of kidney stones should avoid morus albus.

TOXICOLOGY:
No toxicity, carcinogenicity, or teratogenicity has been reported.

Close

Close

URIC ACID BALANCER
Liver Pathway
BLACK CURRANT OIL

SOURCE AND CHEMICAL COMPOSITION:
Black currant oil is produced from the black currant seeds. The oil was shown to contain fatty acids: gamma- and alpha-linolenic acids, and stearidonic acid, as well as anthocyanins, flavonoids, and 2 nitrile-containing compounds.

MECHANISM OF ACTION:
It has been shown that black currant oil inhibits xanthine oxidase activity. Furthermore, the oil also possesses an anti-inflammatory activity.

HUMAN EXPERIENCE:
Although black currant oil has been broadly used in humans for various conditions, the published data is mainly focused on the use of the oil in patients with rheumatoid arthritis. No formal clinical trials have been conducted to assess the role of black currant oil in uric acid metabolism.

PREGNANCY AND LACTATION:
The remedy should be avoided during pregnancy and lactation.

INTERACTIONS:
Black currant oil contains gamma-linolenic acid which was demonstrated to suppress platelet aggregation and increase bleeding time. Therefore, a potential interaction exists between black currant oil and anticoagulants, such as warfarin.

ADVERSE REACTIONS:
No adverse reactions have been reported. The black currant oil should be used with caution in epileptic patients because of reports that gamma-linoleic acid containing supplements can lower seizure threshold.

TOXICOLOGY:
No toxicity, carcinogenicity, or teratogenicity has been reported.

Close

Close

URIC ACID ELIMINATOR
Intestinal Pathway
YUCCA ROOT (4:1) EXTRACT
CELERY SEED EXTRACT
MILK THISTLE SEED (SILYMARIN)

SOURCE AND CHEMICAL COMPOSITION:
YUCCA EXTRACT is an extract of Yucca schidigera containing steroidal saponins, resveratrol and a number stilbenes
CELERY SEED EXTRACT contains alpha-linoleic acid, flavonoids, coumarins, 3-N-butyl phthalide, beta-eudesmol as well as varios vitamins and microelements.
SILYMARIN is a mixture of at least 4 closely related flavonolignans from seeds of Milk Thistle.

MECHANISM OF ACTION:
YUCCA EXTRACT was shown to normalize gastrointestinal microflora and facilitate intestinal elimination of uric acid.
CELERY CEED EXTRACT normalizes gastrointestinal microflora responsible for uric acid degradation and facilitate uric acid elimination via kidneys.
SILYMARIN possesses hepatoprotective activity, it also inhibits xanthine oxidase and stimulates bile flow therefore facilitating the traffic of the synthesized uric acid via gastrointestinal tract.

HUMAN EXPERIENCE:
All three remedies have been used in complementary medicine as anti-inflammatory, anti-arthritic and anti-gouty products for a long time. However, the focused clinical trials on the effects of these remedies on uric acid metabolism have not been performed.

PREGNANCY AND LACTATION:
The remedy should be avoided during pregnancy and lactation.

INTERACTIONS:
The ingredients can potentially interact with anti-hypertensive agents, diuretics, warfarin, antibiotics and prevent absorption of lipid soluble vitamins (A, D, E and K).

ADVERSE REACTIONS:
The reported adverse reactions include increased photosensitivity, occasional diarrhea and nausea.

TOXICOLOGY:
No toxicity, carcinogenicity, or teratogenicity has been reported.

Close